Virus biophysics group
In this lab we try to understand viruses by studying their proteins using biochemistry and biophysical techniques.
We focus on endemic viruses regarding their maturation process and manifestation in the blood of patients.
We study the mechanisms and energetics of protein structure, folding and binding with an eye into the introduction of novel antiviral drugs and better diagnostics.
Mariano Dellarole, Ph.D.
+54 11 4899-5500 int 6506
mdellarole@cibion.conicet.gov.ar
- Facundo Gallo – Ph. D. candidate
- Yanina Godoy – UTN
- Tobías Ledesma – Fellow
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Sánchez IE, Dellarole M, Gaston K, de Prat Gay G. Comprehensive comparison of the interaction of the E2 master regulator with its cognate target DNA sites in 73 human papillomavirus types by sequence statistics. Nucleic Acids Res. 2008 Feb;36(3):756-69. doi: 10.1093/nar/gkm1104. Epub 2007 Dec 15. PMID: 18084026; PMCID: PMC2241901. View publication
- Dellarole M, Caro JA, Roche J, Fossat M, Barthe P, García-Moreno E B, Royer CA, Roumestand C. Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties. J Am Chem Soc. 2015 Jul 29;137(29):9354-62. doi: 10.1021/jacs.5b04320. Epub 2015 Jul 16. PMID: 26135981. View publication
- Dellarole M, Kobayashi K, Rouget JB, Caro JA, Roche J, Islam MM, Garcia-Moreno E B, Kuroda Y, Royer CA. Probing the physical determinants of thermal expansion of folded proteins. J Phys Chem B. 2013 Oct 24;117(42):12742-9. doi: 10.1021/jp401113p. Epub 2013 May 21. PMID: 23646824. View publication
- Vaney MC, Dellarole M, Duquerroy S, Medits I, Tsouchnikas G, Rouvinski A, England P, Stiasny K, Heinz FX, Rey FA. Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. Nat Commun. 2022 Jun 28;13(1):3718. doi: 10.1038/s41467-022-31111-y. PMID: 35764616; PMCID: PMC9239988. View publication
- Benfrid S, Park KH, Dellarole M, Voss JE, Tamietti C, Pehau-Arnaudet G, Raynal B, Brûlé S, England P, Zhang X, Mikhailova A, Hasan M, Ungeheuer MN, Petres S, Biering SB, Harris E, Sakuntabhai A, Buchy P, Duong V, Dussart P, Coulibaly F, Bontems F, Rey FA, Flamand M. Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins. EMBO Rep. 2022 Jul 5;23(7):e53600. doi: 10.15252/embr.202153600. Epub 2022 May 24. PMID: 35607830. View publication