Biofísica de Virus: publicaciones del  Dr. Mariano Dellarole


  • Roche J, Caro JA, Dellarole M, Guca E, Royer CA, García-Moreno BE, Garcia AE, Roumestand C. Structural, energetic, and dynamic responses of the native state ensemble of staphylococcal nuclease to cavity-creating mutations. Proteins. 2013 Jun;81(6):1069-80. doi: 10.1002/prot.24231. Epub 2013 Apr 27. PMID: 23239146.
    EMBO reports (2022). Leer publicación


  • Souheyla Benfrid, Kyu-Ho Park, Mariano Dellarole, James E. Voss, Carole Tamietti, Gérard Pehau Arnaudet,
    Bertrand Raynal, Sébastien Brûlé. Patrick England, Xiaokang Zhang, Anastassia Mikhailova, Marie Noëlle Ungeheuer, Stéphane Petres, Scott B. Biering, Eva Harris, Anavaj Sakunthabaï, Philippe Buchy, Veasna Duong, Philippe Dussart, Fasséli Coulibaly, François Bontems, Félix  A. Rey. A novel complex formed between the flaviviral non-structural NS1  protein and plasma lipoproteins. (2021). Leer publicación


  • Belotserkovsky I, Brunner K, Pinaud L, Rouvinski A, Dellarole M, Baron B, Dubey G, Samassa F, Parsot C, Sansonetti P, Phalipon A. Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes. mBio. 2018 Feb 13;9(1):e02309-17. doi: 10.1128/mBio.02309-17. PMID: 29440574; PMCID: PMC5821077. Leer publicación


  • Rey FA, Stiasny K, Vaney MC, Dellarole M, Heinz FX. The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design. EMBO Rep. 2018 Feb;19(2):206-224. doi: 10.15252/embr.201745302. Epub 2017 Dec 27. PMID: 29282215; PMCID: PMC5797954. Leer publicación


  • Fossat MJ, Dao TP, Jenkins K, Dellarole M, Yang Y, McCallum SA, Garcia AE, Barrick D, Roumestand C, Royer CA. High-Resolution Mapping of a Repeat Protein Folding Free Energy Landscape. Biophys J. 2016 Dec 6;111(11):2368-2376. doi: 10.1016/j.bpj.2016.08.027. PMID: 27926838; PMCID: PMC5153537. Leer publicación


  • Saotome T, Nakamura S, Islam MM, Nakazawa A, Dellarole M, Arisaka F, Kidokoro S, Kuroda Y. Unusual Reversible Oligomerization of Unfolded Dengue Envelope Protein Domain 3 at High Temperatures and Its Abolition by a Point Mutation. Biochemistry. 2016 Aug 16;55(32):4469-75. doi: 10.1021/acs.biochem.6b00431. Epub 2016 Aug 4. PMID: 27433922. Ver publicación


  • Roche J, Dellarole M, Royer CA, Roumestand C. Exploring the Protein Folding Pathway with High-Pressure NMR: Steady-State and Kinetics Studies. Subcell Biochem. 2015;72:261-78. doi: 10.1007/978-94-017-9918-8_13. PMID: 26174386. Ver publicación



  • Dellarole M, Caro JA, Roche J, Fossat M, Barthe P, García-Moreno E B, Royer CA, Roumestand C. Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties. J Am Chem Soc. 2015 Jul 29;137(29):9354-62. doi: 10.1021/jacs.5b04320. Epub 2015 Jul 16. PMID: 26135981. Ver publicación


  • Mesnage S, Dellarole M, Baxter NJ, Rouget JB, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K, Foster SJ, Williamson MP. Molecular basis for bacterial peptidoglycan recognition by LysM domains. Nat Commun. 2014 Jun 30;5:4269. doi: 10.1038/ncomms5269. PMID: 24978025; PMCID: PMC4083421. Ver publicación



  • Sibille N, Dellarole M, Royer C, Roumestand C. Measuring residual dipolar couplings at high hydrostatic pressure: robustness of alignment media to high pressure. J Biomol NMR. 2014 Jan;58(1):9-16. doi: 10.1007/s10858-013-9798-7. Epub 2013 Dec 1. PMID: 24292655. Ver publicación


  • Dellarole M, Royer CA. High-pressure fluorescence applications. Methods Mol Biol. 2014;1076:53-74. doi: 10.1007/978-1-62703-649-8_4. PMID: 24108623. Ver publicación


  • Roche J, Dellarole M, Caro JA, Norberto DR, Garcia AE, Garcia-Moreno B, Roumestand C, Royer CA. Effect of internal cavities on folding rates and routes revealed by real-time pressure-jump NMR spectroscopy. J Am Chem Soc. 2013 Oct 2;135(39):14610-8. doi: 10.1021/ja406682e. Epub 2013 Sep 18. PMID: 23987660. Ver publicación


  • Guca E, Roumestand C, Vallone B, Royer CA, Dellarole M. Low-cost equilibrium unfolding of heme proteins using 2 μl samples. Anal Biochem. 2013 Dec 1;443(1):13-5. doi: 10.1016/j.ab.2013.08.006. Epub 2013 Aug 16. PMID: 23958270. Ver publicación


  • Dellarole M, Kobayashi K, Rouget JB, Caro JA, Roche J, Islam MM, Garcia-Moreno E B, Kuroda Y, Royer CA. Probing the physical determinants of thermal expansion of folded proteins. J Phys Chem B. 2013 Oct 24;117(42):12742-9. doi: 10.1021/jp401113p. Epub 2013 May 21. PMID: 23646824. Ver publicación



  • Dellarole M, Roumestand C, Royer C, Lecomte JT. Volumetric properties underlying ligand binding in a monomeric hemoglobin: a high-pressure NMR study. Biochim Biophys Acta. 2013 Sep;1834(9):1910-22. doi: 10.1016/j.bbapap.2013.04.016. Epub 2013 Apr 22. PMID: 23619242. Ver publicación


  • Roche J, Caro JA, Dellarole M, Guca E, Royer CA, García-Moreno BE, Garcia AE, Roumestand C. Structural, energetic, and dynamic responses of the native state ensemble of staphylococcal nuclease to cavity-creating mutations. Proteins. 2013 Jun;81(6):1069-80. doi: 10.1002/prot.24231. Epub 2013 Apr 27. PMID: 23239146. Ver publicación


  • Roche J, Dellarole M, Caro JA, Guca E, Norberto DR, Yang Y, Garcia AE, Roumestand C, García-Moreno B, Royer CA. Remodeling of the folding free energy landscape of staphylococcal nuclease by cavity-creating mutations. Biochemistry. 2012 Nov 27;51(47):9535-46. doi: 10.1021/bi301071z. Epub 2012 Nov 13. PMID: 23116341. Ver publicación


  • Dellarole M, Sánchez IE, de Prat Gay G. Thermodynamics of cooperative DNA recognition at a replication origin and transcription regulatory site. Biochemistry. 2010 Dec 7;49(48):10277-86. doi: 10.1021/bi1014908. Epub 2010 Nov 10. PMID: 21047141; PMCID: PMC3091369. Ver publicación



  • Sánchez IE, Ferreiro DU, Dellarole M, de Prat-Gay G. Experimental snapshots of a protein-DNA binding landscape. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7751-6. doi: 10.1073/pnas.0911734107. Epub 2010 Apr 7. PMID: 20375284; PMCID: PMC2867883. Ver publicación


  • Smal C, Wetzler DE, Dantur KI, Chemes LB, Garcia-Alai MM, Dellarole M, Alonso LG, Gaston K, de Prat-Gay G. The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins. Biochemistry. 2009 Dec 22;48(50):11939-49. doi: 10.1021/bi901415k. PMID: 19899811. Ver publicación


  • Eliseo T, Sánchez IE, Nadra AD, Dellarole M, Paci M, de Prat Gay G, Cicero DO. Indirect DNA readout on the protein side: coupling between histidine protonation, global structural cooperativity, dynamics, and DNA binding of the human papillomavirus type 16 E2C domain. J Mol Biol. 2009 May 1;388(2):327-44. doi: 10.1016/j.jmb.2009.03.013. Epub 2009 Mar 12. PMID: 19285507. Ver publicación


  • Sánchez IE, Dellarole M, Gaston K, de Prat Gay G. Comprehensive comparison of the interaction of the E2 master regulator with its cognate target DNA sites in 73 human papillomavirus types by sequence statistics. Nucleic Acids Res. 2008 Feb;36(3):756-69. doi: 10.1093/nar/gkm1104. Epub 2007 Dec 15. PMID: 18084026; PMCID: PMC2241901. Ver publicación



  • Dellarole M, Sánchez IE, Freire E, de Prat-Gay G. Increased stability and DNA site discrimination of "single chain" variants of the dimeric beta-barrel DNA binding domain of the human papillomavirus E2 transcriptional regulator. Biochemistry. 2007 Oct 30;46(43):12441-50. doi: 10.1021/bi701104q. Epub 2007 Oct 4. PMID: 17915949. Ver publicación


  • Cicero DO, Nadra AD, Eliseo T, Dellarole M, Paci M, de Prat-Gay G. Structural and thermodynamic basis for the enhanced transcriptional control by the human papillomavirus strain-16 E2 protein. Biochemistry. 2006 May 30;45(21):6551-60. doi: 10.1021/bi060123h. PMID: 16716065. Ver publicación


  • Ferreiro DU, Dellarole M, Nadra AD, de Prat-Gay G. Free energy contributions to direct readout of a DNA sequence. J Biol Chem. 2005 Sep 16;280(37):32480-4. doi: 10.1074/jbc.M505706200. Epub 2005 Jul 5. PMID: 16000299. Ver publicación




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