BIOANALYTICAL MASS SPECTROMETRY GROUP

 Principal Researcher:

María Eugenia Monge, Ph.D.

T: +54 11 4899-5500 int 5614
E: maria.monge@cibion.conicet.gov.ar
ORCID

 

ACTIVITIES

Our research interests involve the field of mass spectrometry with focus on metabolomics for biomarker discovery and analytical method development for complex sample analysis with applications in biomedicine, pharmaceutical analysis, and atmospheric chemistry.

GROUP MEMBERS

Gabriel Riquelme - PhD candidate,  CONICET Fellow
Maximilian A. Rey - PhD candidate,  CONICET Fellow
Nicolás Zabalegui - PhD candidate,  CONICET Fellow
Mariela Videla, Ph.D. - Associate Professional CONICET
Manuela Romina Martinefski, Ph.D. - Research staff  CONICET
Malena Manzi, Ph.D. - Research staff  CONICET
Mariela Andrea García - Assistant Professional CONICET

SELECTED PUBLICATIONS   -   -> Full list of publications

Malena Manzi, Martín Palazzo, María Elena Knott, Pierre Beauseroy, Patricio Yankilevich, María Isabel Giménez, and María Eugenia Monge, "Coupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma", Journal of Proteome Research  2021;20 (1): 841-857   DOI: 10.1021/acs.jproteome.0c00663.  https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00663

M.R. Martinefski, B. Elguero, M. E. Knott, D. Gonilski, L. Tedesco, J. M. Gurevich Messina, C. Pollak, E. Arzt, and M. E. Monge* “Mass Spectrometry-based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism” Journal of Proteome Research 2021;20 (1): 786-803  DOI: 10.1021/acs.jproteome.0c00655

G. Riquelme,  N. Zabalegui, P. Marchi, C. M. Jones y  M. E. Monge*
“A Python-Based Pipeline for Preprocessing LC-MS Data for Untargeted Metabolomics Workflows”
En   Metabolites, 10 (2020) 416.  DOI: 10.3390/metabo10100416

“Seawater Analysis by Ambient Mass Spectrometry-Based Seaomics”  N. Zabalegui, M. Manzi, A. Depoorter, N. Hayeck, M. Roveretto, C. Li, M. van Pinxteren, H. Herrmann, C. George, and M. E. Monge.  Atmospheric Chemistry and Physics 20(2020) 6243–6257 DOI: 10.5194/acp-20-6243-2020

Improving Diagnosis of Genitourinary Cancers: Biomarker Discovery Strategies through Mass Spectrometry-based Metabolomics”,  M. Manzi, G. Riquelme, N. Zabalegui and M. E. Monge. Journal of Pharmaceutical and Biomedical Analysis 178 (2020) 112905

“Metabolic Footprinting of a Clear Cell Renal Cell Carcinoma in vitro Model for Human Kidney Cancer Detection” M. E. Knott, M. Manzi, N. Zabalegui, M. O. Salazar, L. I. Puricelli, and M. E. Monge. Journal of Proteome Research 17 (2018) 3877–3888.

“Feasibility of Detecting Prostate Cancer by Ultraperformance Liquid Chromatography−Mass Spectrometry Serum Metabolomics”, X. Zang, C. M. Jones, T. Q. Long, M. E. Monge, M. Zhou, L. D. Walker, R. Mezencev, A. Gray, J. F. McDonald, and F. M. Fernández.  Journal of Proteome Research 13 (2014) 3444-3454

“A Tiered Analytical Approach for Investigating Poor Quality Emergency Contraceptives”, M. E. Monge, P. Dwivedi, M. Zhou, M. Payne, C. Harris, B. House, y. Juggins, P. Cizmarik, P. N. Newton, F. M. Fernández, D. Jenkins.   PLoS ONE 9 (4) (2014) :e95353

“Ion Mobility and Liquid Chromatography-Mass Spectrometry Strategies for Exhaled Breath Condensate Glucose Quantitation in Cystic Fibrosis Studies" M. E. Monge, J. J. Pérez, P. Dwivedi, M. Zhou, N. A. McCarty, A. A. Stecenko, F. M. Fernández.   Rapid Communications in Mass Spectrometry 27 (2013) 2263-2271

“Alternative pathway for atmospheric particles growth", M. E. Monge, T. Rosenørn, O. Favez, M. Müller, G. Adler, A. A.Riziq, Y. Rudich, C. George, B. D’Anna. Proceedings of the National Academy of Sciences 109 (2012) 6840-6844

“Light changes the atmospheric reactivity of soot”, M.E. Monge, B. D’Anna, L. Mazri, A. Giroir-Fendler, M. Ammann, D.J. Donaldson, and C. George.   Proceedings of the National Academy of Sciences 107 (2010) 6605-6609

SCIENCE COMMUNICATION

Interview Noche Argentina de los Investigadores
Visit to the mass espectrometry lab at CIBION. Noche Europea de Los Investigadores
Interview. El Cronista newspaper. En búsqueda de la exactitud
Metabolomics Interview in MetaboNews to Dr. María Eugenia Monge
Participacion in network :  “Early-career Members Network” (EMN) , Metabolomics  Society. (Dra. María Eugenia Monge and  Lic. Nicolás Zabalegui )

SOCIAL NETWORKS

Keynote talk of María Eugenia Monge at  CaracterizAR 2020
Check it out  youtu.be/fb3B2mBMlKA?t=2578

COURSES FOR GRADUATE STUDENTS AND POSTDOCS
International course CABBIO 2019 in CIBION.
Advance course: Estudios metabolómicos no dirigidos (untargeted) empleando espectrometría de masas y resonancia magnética nuclear como plataformas analíticas.
International course CABBIO 2017.

COLLABORATORS

Christina M. Jones, National Institute of Standards and Technology (USA)
Facundo M. Fernández, Georgia Institute of Technology (Atlanta, USA).
Christian George, IRCELYON-CNRS (Lyon, France).
Donatella Bulone, Istituto di Biofisica-CNR (Palermo, Italia).
Lydia I. Puricelli, Área Investigación-Instituto de Oncología "Ángel H. Roffo" (CABA, Argentina).
María Isabel Giménez, Hospital Italiano de Buenos Aires (CABA, Argentina).
Mario Salazar, IIDEFAR (Rosario, Argentina).
Pablo Hoijemberg, CIBION - CONICET (CABA, Argentina).
Adriana Kolender, CIHIDECAR-CONICET, DQO-FCEN, UBA (Buenos Aires, Argentina).
Hartmut Herrmann, Leibniz Institute for. Tropospheric Research, TROPOS, (Leipzig, Alemania).
Abdelwahid Mellouki, Institut de Combustion Aérothermique Réactivité et Environnement, ICARE, CNRS (Orleáns, Francia).
Rosa Erra-Balsells, CIHIDECAR-CONICET, DQO-FCEN, UBA (Buenos Aires, Argentina).
Patricio Yankilevich, IBioBA -MPSP (CABA, Argentina).
Mariela Bollini, CIBION-CONICET (CABA-ARGENTINA).
Eduardo Arzt, IBioBA-MPSP (CABA, Argentina).
Damián Refojo, IBioBA-MPSP (CABA, Argentina).
Carolina Pérez Castro, IBioBA-MPSP (CABA, Argentina).
Lucas Pontel, IBioBA-MPSP (CABA, Argentina).

METHODS
- Mass Spectrometry
- Ultra Performance Liquid Chromatography
- Multivariate Statistical Analysis (Chemometrics/Bioinformatics)